Issue 1, 2020

A cobalt corrole/carbon nanotube enables simultaneous electrochemical monitoring of oxygen and ascorbic acid in the rat brain

Abstract

It is of interest to in vivo monitor the co-dynamics of different substances. However, the tracking of multiple species is still challenging. In this work, we demonstrate an in vivo electrochemical method by using multi-potential step amperometry to in vivo detect ascorbic acid (AA) and oxygen (O2) simultaneously. In order to achieve good selectivity and high sensitivity for both AA and O2, we design a cobalt corrole [Co(tpfc)(py)2] (tpfc = 5,10,15-tris(penta-fluorophenyl) corrole, py = pyridine, denoted as Co-TPFC) and carbon nanotube nanocomposite to modify a carbon fiber microelectrode (Co-TPFC/MWNT/CFE). This Co-TPFC/MWNT/CFE exhibits excellent electrocatalytic properties towards the reduction of O2 preceding a 4e process and facilitates the oxidation of AA at low potential in the physiological environment. Based on this, we realize simultaneous detection of AA and O2 using two-potential steps (one cathodic (−0.2 V) and the other anodic (+0.05 V)) with 1 second step time. Both in vitro and in vivo experiments proved the feasibility of this method. This demonstrated strategy is useful for us to understand various physiological and pathological processes associated with O2 and AA co-dynamics, and also provides an idea for detecting multiple substances simultaneously.

Graphical abstract: A cobalt corrole/carbon nanotube enables simultaneous electrochemical monitoring of oxygen and ascorbic acid in the rat brain

Article information

Article type
Paper
Submitted
30 Sep 2019
Accepted
17 Oct 2019
First published
22 Oct 2019

Analyst, 2020,145, 70-75

A cobalt corrole/carbon nanotube enables simultaneous electrochemical monitoring of oxygen and ascorbic acid in the rat brain

X. Liu, T. Feng, W. Ji, Z. Wang and M. Zhang, Analyst, 2020, 145, 70 DOI: 10.1039/C9AN01946D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements