Issue 28, 2019

Synthesis of indoles and quinazolines via additive-controlled selective C–H activation/annulation of N-arylamidines and sulfoxonium ylides

Abstract

Selective synthesis of indole and quinazoline products was achieved through a precise control of the C–H activation/annulation by changing the additives from NaOAc to CuF2/CsOAc. This strategy constructs indole and quinazoline scaffolds efficiently, and hence is of great interest in pharmaceutical, agricultural and chemical industries.

Graphical abstract: Synthesis of indoles and quinazolines via additive-controlled selective C–H activation/annulation of N-arylamidines and sulfoxonium ylides

Associated articles

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Article information

Article type
Communication
Submitted
08 Feb 2019
Accepted
06 Mar 2019
First published
06 Mar 2019

Chem. Commun., 2019,55, 4039-4042

Synthesis of indoles and quinazolines via additive-controlled selective C–H activation/annulation of N-arylamidines and sulfoxonium ylides

R. Lai, X. Wu, S. Lv, C. Zhang, M. He, Y. Chen, Q. Wang, L. Hai and Y. Wu, Chem. Commun., 2019, 55, 4039 DOI: 10.1039/C9CC01146C

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