A fluorinated aza-BODIPY derivative for NIR fluorescence/PA/19F MR tri-modality in vivo imaging

Lianhua Liu; Yaping Yuan; Yuqi Yang; Michael T. McMahon; Shizhen Chen; Xin Zhou

doi:10.1039/C9CC01253B

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A fluorinated aza-BODIPY derivative for NIR fluorescence/PA/¹⁹F MR tri-modality in vivo imaging†

Lianhua Liu,^a Yaping Yuan,^a Yuqi Yang,^a Michael T. McMahon,^bc Shizhen Chen*^a and Xin Zhou

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China
E-mail: chenshizhen@wipm.ac.cn, xinzhou@wipm.ac.cn

^b Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

^c F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21287, USA

Abstract

A fluorinated aza-BODIPY derivative BDPF was developed as a small molecule contrast agent, which displayed highly efficient near infrared fluorescence/photoacoustic/¹⁹F MR tri-modality tumor imaging.

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Article information

DOI: https://doi.org/10.1039/C9CC01253B
Article type: Communication
Submitted: 13 Feb 2019
Accepted: 17 Apr 2019
First published: 17 Apr 2019

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Chem. Commun., 2019,55, 5851-5854

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A fluorinated aza-BODIPY derivative for NIR fluorescence/PA/¹⁹F MR tri-modality in vivo imaging

L. Liu, Y. Yuan, Y. Yang, M. T. McMahon, S. Chen and X. Zhou, Chem. Commun., 2019, 55, 5851 DOI: 10.1039/C9CC01253B

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Chemical Communications