New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Philipp Stockmann; Marta Gozzi; Robert Kuhnert; Menyhárt B. Sárosi; Evamarie Hey-Hawkins

doi:10.1039/C9CS00197B

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New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Philipp Stockmann,

^a Marta Gozzi,

^a Robert Kuhnert,

^a Menyhárt B. Sárosi

*^a and Evamarie Hey-Hawkins

*^a

Author affiliations

* Corresponding authors

^a Universität Leipzig, Fakultät für Chemie und Mineralogie, Institut für Anorganische Chemie, Johannisallee 29, 04103 Leipzig, Germany
E-mail: menyhart.sarosi@uni-leipzig.de, hey@uni-leipzig.de
Fax: +49-341-9739319
Tel: +49-341-9736151

Abstract

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential “new keys for old locks” which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.

This article is part of the themed collection: Contemporary Research in Boron Chemistry

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DOI: https://doi.org/10.1039/C9CS00197B
Article type: Tutorial Review
Submitted: 14 Mar 2019
First published: 19 Jun 2019
This article is Open Access

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Chem. Soc. Rev., 2019,48, 3497-3512

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New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

P. Stockmann, M. Gozzi, R. Kuhnert, M. B. Sárosi and E. Hey-Hawkins, Chem. Soc. Rev., 2019, 48, 3497 DOI: 10.1039/C9CS00197B

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New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

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