Issue 8, 2019

Effect of low-ratio n-6/n-3 PUFA on blood glucose: a meta-analysis

Abstract

Objective: The aim of this meta-analysis was to investigate the effect of increasing dietary low-ratio n-6/n-3 polyunsaturated fatty acid (PUFA) intake on blood glucose and other related indicators. Methods: We systematically searched randomized controlled trials of low-ratio n-6/n-3 PUFA intervention on PubMed, Embase, Cochrane library and related references up to August 2018. The change values were calculated as the weighted mean difference (WMD) by using a random-effect model. Results: Eleven randomized controlled trials were included. No significant effect of dietary low-ratio n-6/n-3 PUFA supplementation was observed on fasting blood glucose (WMD: 0.057 mmol L−1; 95% CI: −0.090 to 0.204 mmol L−1), insulin (WMD: −0.757 mIU L−1; 95% CI: −2.419 to 0.904 mIU L−1), insulin resistance index (WMD: −0.201; 95% CI: −0.566 to 0.165), and glycosylated hemoglobin (WMD: −0.063%; 95% CI: −0.061 to 0.186%). Subgroup analysis showed that the effect of low-ratio n-6/n-3 PUFA on the reduction of the plasma insulin level in North America (WMD: −3.473 mIU L−1; 95% CI: −5.760 to −1.185 mIU L−1) was more obvious than that in Asian countries (WMD: −0.797 mIU L−1; 95% CI: −2.497 to 0.902 mIU L−1) and European countries (WMD: −0.063 mIU L−1; 95% CI: −0.061 to 0.186 mIU L−1). In the subgroup of diabetic subjects, low-ratio n-6/n-3 PUFA supplementation can decrease the plasma insulin level (WMD: −3.010 mIU L−1; 95% CI: −5.371 to −0.648 mIU L−1) and insulin resistance index (WMD: −0.460; 95% CI: −0.908 to −0.012). When the intervention period was longer than 8 weeks, low-ratio n-6/n-3 PUFA supplementation could also decrease the plasma insulin level (WMD: −2.782 mIU L−1; 95% CI: −4.946 to −0.618 mIU L−1). No significant publication bias was observed for all blood glucose and other related indicators as suggested by Begg's test and Egger's test. Conclusion: Our meta-analysis found that low-ratio n-6/n-3 PUFA supplementation could improve the glucose metabolism by reducing the insulin and insulin resistance in the diabetic patients. Low-ratio n-6/n-3 PUFA supplementation could reduce the plasma insulin level when the supplementation duration was longer than 8 weeks.

Graphical abstract: Effect of low-ratio n-6/n-3 PUFA on blood glucose: a meta-analysis

Supplementary files

Article information

Article type
Paper
Submitted
18 Feb 2019
Accepted
05 May 2019
First published
10 May 2019

Food Funct., 2019,10, 4557-4565

Effect of low-ratio n-6/n-3 PUFA on blood glucose: a meta-analysis

N. Li, H. Yue, M. Jia, W. Liu, B. Qiu, H. Hou, F. Huang and T. Xu, Food Funct., 2019, 10, 4557 DOI: 10.1039/C9FO00323A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements