Issue 11, 2019
From the journal:

Organic & Biomolecular Chemistry

Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate†

Haiqing He,ab   Dong Chen,ab   Xiaomei Li,ab   Chengji Li,ab   Jin-Hua Zhao*a  and  Hong-Bo Qin ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, P. R. China
E-mail: qinhongbo@mail.kib.ac.cn, zhaojinhua@mail.kib.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

We described the chemical synthesis of a sulfated trisaccharide repeating unit of fucosylated chondroitin sulfate (FCS), which has significant anticoagulant activity. Well-functionalized monosaccharides were readily prepared, and highly efficient glycosylations using a common activator (NIS/TfOH) were also presented. The synthesized trisaccharide 4 could be used to extend oligosaccharide sequences.

Graphical abstract: Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate

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Article information

DOI
https://doi.org/10.1039/C9OB00057G
Article type
Communication
Submitted
09 Jan 2019
Accepted
30 Jan 2019
First published
31 Jan 2019

Org. Biomol. Chem., 2019,17, 2877-2882

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Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate

H. He, D. Chen, X. Li, C. Li, J. Zhao and H. Qin, Org. Biomol. Chem., 2019, 17, 2877 DOI: 10.1039/C9OB00057G

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