The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer

Thomas Scattolin; Enrica Bortolamiol; Stefano Palazzolo; Isabella Caligiuri; Tiziana Perin; Vincenzo Canzonieri; Nicola Demitri; Flavio Rizzolio; Luigi Cavallo; Busra Dereli; Manoj V. Mane; Steven P. Nolan; Fabiano Visentin

doi:10.1039/D0CC03883K

The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer†

Thomas Scattolin,^a Enrica Bortolamiol,^b Stefano Palazzolo,^c Isabella Caligiuri,^c Tiziana Perin,^c Vincenzo Canzonieri,

^cd Nicola Demitri,

^e Flavio Rizzolio,*^bc Luigi Cavallo,

^f Busra Dereli,^f Manoj V. Mane,^f Steven P. Nolan

^a and Fabiano Visentin

*^b

Author affiliations

* Corresponding authors

^a Department of Chemistry and Center for Sustainable Chemistry, Ghent University, Krijgslaan 281 (S-3), Ghent, Belgium

^b Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari, Campus Scientifico Via Torino 155, Venezia-Mestre 30174, Italy
E-mail: fvise@unive.it, flavio.rizzolio@unive.it

^c Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano 33081, Italy

^d Department of Medical, Surgical and Health Sciences, Università degli Studi di Trieste, Strada di Fiume 447, Trieste, Italy

^e Elettra – Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, Basovizza 34149, Trieste, Italy

^f KAUST Catalysis Centre, KCC, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia

Abstract

A new dinuclear Pd(I) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

Chemical Communications

The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer†

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The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer

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