Issue 89, 2020

Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification

Abstract

A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.

Graphical abstract: Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2020
Accepted
05 Oct 2020
First published
09 Oct 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 13856-13859

Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification

Y. Zhang, A. Gambardella, M. Üçüncü, J. Geng, J. Clavadetscher, M. Bradley and A. Lilienkampf, Chem. Commun., 2020, 56, 13856 DOI: 10.1039/D0CC04591H

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