Issue 8, 2021
From the journal:

Chemical Communications

A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma†

Ping Tan,‡a   Weihua Zhuang, ORCID logo ‡b   Shufen Li,b   Jiapeng Zhang,a   Hang Xu,a   Lu Yang,a   Yanbiao Liao,c   Mao Chen*bc  and  Qiang Wei ORCID logo *a  

* Corresponding authors

a Department of Urology, Institute of Urology, Huaxi MR Research Center (HMRRC), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu 610064, P. R. China
E-mail: weiqiang@scu.edu.cn

b Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu 610064, P. R. China

c Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu 610064, P. R. China
E-mail: hmaochen@vip.sina.com

Abstract

A one-step synthesized LD specific fluorescent probe TTIE with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation is designed and synthesized for LD specific image-guided photodynamic therapy (PDT) in human clear cell renal cell carcinoma (ccRCC) primary cells and tissues.

Graphical abstract: A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma

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Article information

DOI
https://doi.org/10.1039/D0CC07336A
Article type
Communication
Submitted
06 Nov 2020
Accepted
17 Dec 2020
First published
07 Jan 2021

Chem. Commun., 2021,57, 1046-1049

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A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma

P. Tan, W. Zhuang, S. Li, J. Zhang, H. Xu, L. Yang, Y. Liao, M. Chen and Q. Wei, Chem. Commun., 2021, 57, 1046 DOI: 10.1039/D0CC07336A

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