Issue 20, 2020

The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions

Abstract

An efficient and green electrochemical continuous-flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones through the sulfonylation of alkenes with sulfonylhydrazides. The reaction proceeds in a continuous-flow electrolytic cell under metal-free and oxidant-free conditions. A series of activated alkenes were suitable for this system, and the corresponding products were obtained in moderate to good yields. Moreover, reaction scale-up was smoothly achieved using the electrochemical continuous-flow system without changing the reaction conditions.

Graphical abstract: The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
28 Jul 2020
Accepted
07 Sep 2020
First published
10 Sep 2020

Org. Chem. Front., 2020,7, 3223-3228

The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions

J. Xu, Z. Yang, J. Hua, Y. Lin, M. Bian, Y. Li, C. Liu, W. He, Z. Fang and K. Guo, Org. Chem. Front., 2020, 7, 3223 DOI: 10.1039/D0QO00909A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements