Issue 24, 2020

Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury

Abstract

Anastatins A and B, two flavonoid compounds isolated from desert plant Anastatica hierochuntica, have protective activities for primary rat hepatocytes. Anastatins A and B, and their derivatives, were synthesized by our group previously. In this study, the antioxidant activity and cytotoxicity of these compounds were studied using chemical assessment methods, cell proliferation inhibition experiments, and cell oxidative damage models. The best compound, 38c, was used to study the hepatoprotection activity and mechanism by using a CCl4-induced liver injury model in mice. The results show that most of these flavonoid compounds have good antioxidant activity and low cytotoxicity in vitro. Among them, the most potent compound was 38c, which exhibited a protective effect on CCl4-induced hepatic injury by suppressing the amount of CYP2E1. These findings indicate that anastatin flavonoid derivatives have potential therapeutic utility against oxidative hepatic injury.

Graphical abstract: Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury

Article information

Article type
Paper
Submitted
27 Jan 2020
Accepted
26 Mar 2020
First published
14 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 14337-14346

Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury

C. Xiang, M. Cao, A. Miao, F. Gao, X. Li, G. Pan, W. Zhang, Y. Zhang, P. Yu and Y. Teng, RSC Adv., 2020, 10, 14337 DOI: 10.1039/D0RA00822B

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