Issue 7, 2021

Current advances in drug delivery of nanoparticles for respiratory disease treatment

Abstract

Cases of respiratory diseases have been increasing around the world, affecting the health and quality of life of millions of people every year. Chronic respiratory diseases (CRDs) and acute respiratory infections (ARIs) are responsible for many hospital admissions and deaths, requiring sophisticated treatments that facilitate the delivery of therapeutics to specific target sites with controlled release. In this context, different nanoparticles (NPs) have been explored to match this demand, such as lipid, liposome, protein, carbon-based, polymeric, metallic, oxide, and magnetic NPs. The use of NPs as drug delivery systems can improve the efficacy of commercial drugs due to their advantages related to sustained drug release, targeting effects, and patient compliance. The current review presents an updated summary of recent advances regarding the use of NPs as drug delivery systems to treat diseases related to the respiratory tract, such as CRDs and ARIs. The latest applications presented in the literature were considered, and the opportunities and challenges of NPs in the drug delivery field are discussed.

Graphical abstract: Current advances in drug delivery of nanoparticles for respiratory disease treatment

Article information

Article type
Review Article
Submitted
21 Jul 2020
Accepted
15 Dec 2020
First published
18 Dec 2020

J. Mater. Chem. B, 2021,9, 1745-1761

Current advances in drug delivery of nanoparticles for respiratory disease treatment

B. R. C. de Menezes, K. F. Rodrigues, V. M. Schatkoski, R. M. Pereira, R. G. Ribas, T. L. D. A. Montanheiro and G. P. Thim, J. Mater. Chem. B, 2021, 9, 1745 DOI: 10.1039/D0TB01783C

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