SCHEDULED MAINTENANCE
A native mass spectrometry platform identifies HOP inhibitors that modulate the HSP90–HOP protein–protein interaction†
Clinton G. L.
Veale, 
*a
Maria
Mateos-Jiménez,
b
Mahama
Alhassan,
a
Beatriz G.
de la Torre,
d
Fernando
Albericio,
a
C. Logan
Mackay,
b
Adrienne L.
Edkins
c
and
David J.
Clarke
*b
*a
Maria
Mateos-Jiménez,
b
Mahama
Alhassan,
a
Beatriz G.
de la Torre,
d
Fernando
Albericio,
a
C. Logan
Mackay,
b
Adrienne L.
Edkins
c
and
David J.
Clarke
*b
Abstract
Herein we describe a native mass spectromery protein–peptide model as a competent surrogate for the HOP–HSP90 protein–protein interaction (PPI), application of which led to the qualititive identification of two new peptides capable of in vitro PPI disruption. This proof of concept study offers a viable alternative for PPI inhibitor screening.
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