Keggin-type polyoxometalates as Cu(ii) chelators in the context of Alzheimer's disease

Abstract

Two Keggin polyoxometalates were used as new copper ligands to counteract the effects of Cu^II(Amyloid-β) interaction. Their ability to remove Cu^II from Cu^II(Amyloid-β), to stop Cu^II(Amyloid-β) induced formation of reactive oxygen species and to restore apo-like self-assembly of Cu^II(Amyloid-β) was shown.