Issue 15, 2022

Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

Abstract

The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}–{HSQC}–{TOCSY}, where magnetization of non-13C attached protons effectively is channeled from the TOCSY spectrum toward primarily the least sensitive spectrum of HMBC. The experiment is expected to find its place as a full-package NMR method for metabolomics, carbohydrates, peptides and small-molecules in general.

Graphical abstract: Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

Supplementary files

Article information

Article type
Communication
Submitted
26 Nov 2021
Accepted
21 Jan 2022
First published
21 Jan 2022

Chem. Commun., 2022,58, 2516-2519

Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

I. Timári, T. M. Nagy, K. E. Kövér and O. W. Sørensen, Chem. Commun., 2022, 58, 2516 DOI: 10.1039/D1CC06663C

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