Issue 8, 2021

Application of reactor engineering concepts in continuous flow chemistry: a review

Abstract

The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the lines between chemistry and chemical engineering. Current indications point to a future in which flow chemistry and related technologies will be a major player in modern chemical manufacturing and the 4th industrial revolution. In this review we highlight the application of new reactor configurations and designs in the context of either bespoke or commercial flow apparatus specifically related to microwave chemistry, photochemical transformations, electrochemical promoted reactions and multi-phasic reactions. In addition, we look at how 3D printing in reactor design and computer-aided automation is growing within the field and finally describe how innovative solutions are being developed to tackle challenging down-stream processing operations.

Graphical abstract: Application of reactor engineering concepts in continuous flow chemistry: a review

Article information

Article type
Review Article
Submitted
05 Jan 2021
Accepted
04 May 2021
First published
04 May 2021
This article is Open Access
Creative Commons BY-NC license

React. Chem. Eng., 2021,6, 1295-1326

Application of reactor engineering concepts in continuous flow chemistry: a review

N. C. Neyt and D. L. Riley, React. Chem. Eng., 2021, 6, 1295 DOI: 10.1039/D1RE00004G

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