Issue 30, 2021

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Abstract

Metal organic frameworks (MOFs) are a unique class of smart hybrid materials that have recently attracted significant interest for catalysis, separation and biomedical applications. Different strategies have been developed to overcome the limitations of MOFs for bio-applications in order to produce a system with high biocompatibility and biodegradability. In this review, we outline the chemical and physical factors that dictate the biocompatibility and biodegradability characteristics of MOFs including the nature of the metal ions and organic ligands, size, surface properties and colloidal stability. This review includes the in vitro biodegradation and in vivo biodistribution studies of MOFs to better understand their pharmacokinetics, organ toxicity and immune response. Such studies can guide the design of future bio-friendly systems that bring us closer to safely translating these platforms into the pharmaceutical consumer market.

Graphical abstract: Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Article information

Article type
Review Article
Submitted
09 May 2021
Accepted
18 Jun 2021
First published
18 Jun 2021
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2021,9, 5925-5934

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

N. Singh, S. Qutub and N. M. Khashab, J. Mater. Chem. B, 2021, 9, 5925 DOI: 10.1039/D1TB01044A

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