Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Laura Rijns; Lu Su; Konrad Maxeiner; Giulia Morgese; David Y. W. Ng; Tanja Weil; Patricia Y. W. Dankers

doi:10.1039/D2CC06064G

Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels†

Laura Rijns,

^abc Lu Su,

*^d Konrad Maxeiner,^e Giulia Morgese,^f David Y. W. Ng,

^e Tanja Weil^e and Patricia Y. W. Dankers

*^abc

Author affiliations

* Corresponding authors

^a Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands
E-mail: p.y.w.dankers@tue.nl

^b Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

^c Department of Biomedical Engineering, Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands

^d Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands
E-mail: l.su@lacdr.leidenuniv.nl

^e Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany

^f ZHAW Zurich University of Applied Sciences, School of Engineering, Forschungsbereich Polymere Beschichtungen, Technikumstrasse 9, Winterthur 8400, Switzerland

Abstract

Benzene-1,3,5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.

This article is part of the themed collection: Celebrating 10 years of ChemComm Emerging Investigators

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DOI: https://doi.org/10.1039/D2CC06064G
Article type: Communication
Submitted: 14 Nov 2022
Accepted: 16 Jan 2023
First published: 31 Jan 2023
This article is Open Access

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Chem. Commun., 2023,59, 2090-2093

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Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

L. Rijns, L. Su, K. Maxeiner, G. Morgese, D. Y. W. Ng, T. Weil and P. Y. W. Dankers, Chem. Commun., 2023, 59, 2090 DOI: 10.1039/D2CC06064G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels†

Abstract

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Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

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