Base-promoted anaerobic intramolecular cyclization synthesis of 4,5-disubstituted-1,2,3-thiadiazoles

Abstract

An alkali-promoted, transition-metal-free and oxidant-free method to construct 4,5-disubstituted-1,2,3-thiadiazoles from N-tosylhydrazone-bearing thiocarbamates by employing a sustainable intramolecular reaction strategy has been developed. This reaction features high efficiency and good functional group compatibility, readily available starting materials and valuable products. Furthermore, this method has great potential in the synthesis of natural products, pharmaceuticals and materials.