Iron-catalyzed one-pot cyclization and amination of 2-alkynylthioanisoles using nitrosobenzenes as the amine source

Abstract

A direct strategy for the synthesis of 3-phenylaminobenzothiophene via iron-catalyzed cyclization of 2-alkynylthioanisoles and nitrosoarenes is presented in this work. This method realizes the construction and amination of the benzothiophene ring in which nitrosoarenes serve as the amine source. Various functional groups are tolerated in this reaction and the desired products are obtained in moderate yields.