Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Izumi Kato; Yudai Ogawa; Fumika Yakushiji; Jiro Ogura; Masaki Kobayashi; Naoya Shindo; Satoshi Ichikawa; Katsumi Maenaka; Masahiro Sakaitani

doi:10.1039/D3CC03069E

Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease†

Izumi Kato,*^ab Yudai Ogawa,^a Fumika Yakushiji,^ac Jiro Ogura,^d Masaki Kobayashi,^b Naoya Shindo,

^ae Satoshi Ichikawa,

^ac Katsumi Maenaka

*^acefgh and Masahiro Sakaitani*^a

Author affiliations

* Corresponding authors

^a Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
E-mail: maenaka@pharm.hokudai.ac.jp

^b Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
E-mail: izumi_k@pharm.hokudai.ac.jp

^c Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo 060-0812, Japan

^d Department of Pharmacy, Yamagata University Hospital, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata 990-9585, Japan

^e Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

^f Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

^g Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Sapporo 060-0812, Japan

^h Hokkaido University Institute for Vaccine Research & Development, Hokkaido University, Sapporo 060-0812, Japan

Abstract

A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8′′-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease.

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Article information

DOI: https://doi.org/10.1039/D3CC03069E
Article type: Communication
Submitted: 26 Jun 2023
Accepted: 24 Aug 2023
First published: 04 Sep 2023

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Chem. Commun., 2023,59, 12306-12309

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Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

I. Kato, Y. Ogawa, F. Yakushiji, J. Ogura, M. Kobayashi, N. Shindo, S. Ichikawa, K. Maenaka and M. Sakaitani, Chem. Commun., 2023, 59, 12306 DOI: 10.1039/D3CC03069E

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Chemical Communications

Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease†

Abstract

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Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

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