Iron-catalyzed C(sp3)–H phosphorylation via photoinduced LMCT

Abstract

Alkylphosphines demonstrate excellent performance as ligands, catalysts and reagents based on their strong electron-donating properties. However, current methods for synthesizing alkylphosphines are limited to nucleophilic substitution reactions of air-sensitive organometallic reagents. Herein, we report an iron-catalyzed C(sp³)–H phosphorylation enabled by a photoinduced ligand-to-metal charge transfer (LMCT) process, allowing a straightforward synthesis of alkylphosphines from readily accessible chlorophosphines and diverse compounds containing C(sp³)–H bonds.