SCHEDULED MAINTENANCE
α-Amino-p-hydroxyphenylacetic acid was resolved and the isomeric amino-acids were coupled with 6-aminopenicillanic acid by two methods to give both epimers of α-amino-p-hydroxybenzylpenicillin. The epimer derived from (–)-D-α-amino-p-hydroxyphenylacetic acid has a broad spectrum of antibacterial activity and is exceptionally well absorbed into the bloodstream after administration by mouth.
A. A. W. Long, J. H. C. Nayler, H. Smith, T. Taylor and N. Ward, J. Chem. Soc. C, 1971, 1920 DOI: 10.1039/J39710001920
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