Facile Total Synthesis of Isopregomisin
Abstract
Isopregomisin, a diarylbutane-lignan, has been synthesized by a short and efficient route starting from pyrogallol; the synthesis involves a novel selective demethylation reaction and the coupling reaction of the Grignard reagent produced from an aryl bromopropane with (E)-2-tert-butyl-3-phenyloxaziridine.