Issue 11, 2003

Probing the binding dynamics to sodium cholate aggregates using naphthalene derivatives as guests

Abstract

The binding dynamics with bile salt aggregates for a series of naphthalene derivatives of different polarities was studied using fluorescence and laser flash photolysis. Fluorescence was employed to determine the nature of the binding site for each guest and the accessibility of the bound guest to quenchers. Laser flash photolysis was employed to study the mobility of the triplet states of the naphthalenes between the sodium cholate aggregates and the aqueous phase. Primary aggregates, which provide an environment protected from quenchers in the aqueous phase, bind 1- and 2-ethylnaphthalene as guests. The complexation dynamics with this type of aggregate is slow. 1- and 2-Naphthyl-1-ethanol, and 1- and 2-acetonaphthone bind to the secondary aggregates, which provide moderate protection from quenching and faster binding dynamics. The addition of salts lowered the cholate concentration at which primary aggregates were formed, but did not influence the formation of secondary aggregates.

Graphical abstract: Probing the binding dynamics to sodium cholate aggregates using naphthalene derivatives as guests

Supplementary files

Article information

Article type
Paper
Submitted
22 Jul 2003
Accepted
30 Sep 2003
First published
20 Oct 2003

Photochem. Photobiol. Sci., 2003,2, 1140-1151

Probing the binding dynamics to sodium cholate aggregates using naphthalene derivatives as guests

O. Rinco, M. Nolet, R. Ovans and C. Bohne, Photochem. Photobiol. Sci., 2003, 2, 1140 DOI: 10.1039/B308335G

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