Observation of the enhancement in enantioselectivity with conversion for the aziridination of styrene using copper bis(oxazoline) complexes

Observation of the enhancement in enantioselectivity with conversion for the aziridination of styrene using copper bis(oxazoline) complexes†

John Gullick,^a Sophia Taylor,^a Darragh Ryan,^a Paul McMorn,^a Mike Coogan,^a Donald Bethell,^b Philip C. Bulman Page,^c Frederick E. Hancock,^d Frank King^d and Graham J. Hutchings*^a

* Corresponding authors

^a Department of Chemistry, Cardiff University, P.O. Box 912, Cardiff, UK
E-mail: hutch@cf.ac.uk
Fax: 029 20 874075

^b Department of Chemistry, University of Liverpool, Liverpool, UK

^c Department of Chemistry, Loughborough University, Leics, Loughborough, UK

^d Synetix/Johnson Matthey, P.O. Box 1, Billingham, UK

During the aziridination of styrene using copper bis(oxazoline) complexes the ee increases with conversion due to further reactions of the product.