Issue 6, 2005

Chemical genetics to chemical genomics: small molecules offer big insights

Abstract

Chemical genetics is the study of biological systems using small molecule (‘chemical’) intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. This tutorial review has been written to introduce this emerging field to a broad audience and focuses later on areas of biology where either it has made a significant impact, or it has the potential to do so: signalling, cytoskeleton, development, proteinprotein interactions and gene transcription.

Graphical abstract: Chemical genetics to chemical genomics: small molecules offer big insights

Article information

Article type
Tutorial Review
Submitted
20 Sep 2004
First published
28 Feb 2005

Chem. Soc. Rev., 2005,34, 472-482

Chemical genetics to chemical genomics: small molecules offer big insights

D. R. Spring, Chem. Soc. Rev., 2005, 34, 472 DOI: 10.1039/B312875J

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