Issue 5, 2004

The first general method for α-trifluoromethylation of carboxylic acids using BrF3

Abstract

2-Carbomethoxy-1,1-bis(methylsulfide)-1-alkenes, easily made from carboxylic acids, CS2 and MeI, were treated with BrF3 producing eventually the desired α-trifluoromethyl carboxylate derivatives – RCH(CF3)COOR′ – in good yields.

Graphical abstract: The first general method for α-trifluoromethylation of carboxylic acids using BrF3

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2003
Accepted
16 Jan 2004
First published
09 Feb 2004

Chem. Commun., 2004, 594-595

The first general method for α-trifluoromethylation of carboxylic acids using BrF3

A. Hagooly and S. Rozen, Chem. Commun., 2004, 594 DOI: 10.1039/B315705A

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