Issue 5, 2004
From the journal:

Chemical Communications

Highly substituted pyridinesvia tethered imine–enamine (TIE) methodology

Steven A. Raw*a  and  Richard J. K. Taylor*a  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, UK
E-mail: sar113@york.ac.uk, rjkt1@york.ac.uk
Fax: +44(0)1904 434 523
Tel: +44(0)1904 432 606

Abstract

A tethered imine–enamine methodology has been developed for the direct conversion of 1,2,4-triazines into highly substituted pyridines via the inverse electron demand Diels–Alder reaction which avoids the need for a discrete aromatisation step. This TIE methodology has also been applied in one pot reaction cascades involving 1,2,4-triazines and utilising MnO2-mediated tandem oxidation processes (TOPs).

Graphical abstract: Highly substituted pyridines via tethered imine–enamine (TIE) methodology

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Article information

DOI
https://doi.org/10.1039/B316107B
Article type
Communication
Submitted
10 Dec 2003
Accepted
22 Dec 2003
First published
27 Jan 2004

Chem. Commun., 2004, 508-509

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Highly substituted pyridines via tethered imine–enamine (TIE) methodology

S. A. Raw and R. J. K. Taylor, Chem. Commun., 2004, 508 DOI: 10.1039/B316107B

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