Issue 3, 2005
From the journal:

Chemical Communications

5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex†

Varatharasa Thiviyanathan,a   Anoma Somasunderam,a   David E. Volka  and  David G. Gorenstein*a  

* Corresponding authors

a Department of Human Biological Chemistry & Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
E-mail: david@nmr.utmb.edu
Fax: 409 747 6850
Tel: 409 747 6800

Abstract

NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.

Graphical abstract: 5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

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Article information

DOI
https://doi.org/10.1039/B414474K
Article type
Communication
Submitted
21 Sep 2004
Accepted
12 Oct 2004
First published
30 Nov 2004

Chem. Commun., 2005, 400-402

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5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

V. Thiviyanathan, A. Somasunderam, D. E. Volk and D. G. Gorenstein, Chem. Commun., 2005, 400 DOI: 10.1039/B414474K

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