Issue 17, 2005

A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C–N coupling/Michael addition reactions

Abstract

Palladium catalysed C–N bond formation can be used to convert vinyl bromides to the corresponding enamines, which are reacted in situ with alkylidene malonates to provide Michael adducts. The overall transformation results in cine-substitution of the starting vinyl bromide.

Graphical abstract: A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C–N coupling/Michael addition reactions

Supplementary files

Article information

Article type
Communication
Submitted
15 Jun 2005
Accepted
05 Jul 2005
First published
27 Jul 2005

Org. Biomol. Chem., 2005,3, 3094-3095

A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C–N coupling/Michael addition reactions

M. C. Willis, J. Chauhan and W. G. Whittingham, Org. Biomol. Chem., 2005, 3, 3094 DOI: 10.1039/B508464D

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