Issue 35, 2006

Substrate flexibility of a 2,6-dideoxyglycosyltransferase

Abstract

We report the first 2,6-dideoxysugar-O-glycosyltransferase with substrate flexibility at the 2 position, confirm the function of a putative NDP-hexose 2,3-dehydratase in the jadomycin B biosynthetic gene cluster and deduce the substrate flexibility of downstream enzymes in L-digitoxose assembly, enabling reprogramming of biosynthetic gene clusters to modify sugar substituents.

Graphical abstract: Substrate flexibility of a 2,6-dideoxyglycosyltransferase

Supplementary files

Article information

Article type
Communication
Submitted
21 Jun 2006
Accepted
18 Jul 2006
First published
02 Aug 2006

Chem. Commun., 2006, 3738-3740

Substrate flexibility of a 2,6-dideoxyglycosyltransferase

D. L. Jakeman, C. N. Borissow, C. L. Graham, S. C. Timmons, T. R. Reid and R. T. Syvitski, Chem. Commun., 2006, 3738 DOI: 10.1039/B608847C

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