Issue 1, 2007
From the journal:

Chemical Communications

Chemistry and biology of resorcylic acid lactones

Nicolas Winssinger*a  and  Sofia Barluengaa  

* Corresponding authors

a Organic and Bioorganic Chemistry Laboratory, Institut de Science et Ingénierie Supramoléculaires, Université Louis Pasteur, 8 allée Gaspard Monge, Strasbourg, France
E-mail: winssinger@isis-u.strasbg.fr
Fax: +33 (0)3 89 24 51 12
Tel: +33 (0)3 89 24 51 13

Abstract

While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitorshave stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

Graphical abstract: Chemistry and biology of resorcylic acid lactones

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Article information

DOI
https://doi.org/10.1039/B610344H
Article type
Feature Article
Submitted
19 Jul 2006
Accepted
18 Aug 2006
First published
25 Sep 2006

Chem. Commun., 2007, 22-36

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Chemistry and biology of resorcylic acid lactones

N. Winssinger and S. Barluenga, Chem. Commun., 2007, 22 DOI: 10.1039/B610344H

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