Issue 7, 2007

Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction

Abstract

Asymmetric desymmetrization of 4-substituted cyclohexanones using proline amide-catalyzed direct aldol reaction afforded β-hydroxyketones with three stereogenic centers in high enantioselectivities of up to >99% ee.

Graphical abstract: Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
17 Oct 2006
Accepted
09 Nov 2006
First published
30 Nov 2006

Chem. Commun., 2007, 736-738

Enantioselective desymmetrization of prochiral cyclohexanone derivatives via the organocatalytic direct Aldol reaction

J. Jiang, L. He, S. Luo, L. Cun and L. Gong, Chem. Commun., 2007, 736 DOI: 10.1039/B615043H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements