Issue 41, 2007
From the journal:

Chemical Communications

CO and NO in medicine

Brian E. Mann*a  and  Roberto Motterlinib  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Sheffield, UK
E-mail: b.mann@sheffield.ac.uk.
Fax: +44 (0)114 2738673
Tel: +44 (0)114 2229332

b Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
E-mail: r.motterlini@imperial.ac.uk
Fax: +44 (0)208 8693538
Tel: +44 (0)208 8693181

Abstract

The occurrence, role and consequences of CO and NO in biological systems are reviewed. This includes their syntheses by heme oxygenases and NO synthases, their biological targets and the physiological effects of their signals. The use of CO and NO gases in medicine are discussed and methods of delivery are illustrated with particular emphasis on the therapeutic properties of compounds that generate controlled amounts of NO and COin vivo.

Graphical abstract: CO and NO in medicine

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Article information

DOI
https://doi.org/10.1039/B704873D
Article type
Feature Article
Submitted
30 Mar 2007
Accepted
15 May 2007
First published
14 Jun 2007

Chem. Commun., 2007, 4197-4208

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CO and NO in medicine

B. E. Mann and R. Motterlini, Chem. Commun., 2007, 4197 DOI: 10.1039/B704873D

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