Issue 36, 2007

N-Methyl substituted 2′,4′-BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization

Abstract

Oligonucleotides modified with a novel BNA analogue, 2′, 4′-BNANC[N–Me], were synthesized, and in comparison to 2′,4′-BNA (LNA), have similarly high RNA affinity, better RNA selectivity and much higher resistance to nuclease degradation, suggesting that the novel BNA analogue may be particularly useful for antisense approaches.

Graphical abstract: N-Methyl substituted 2′,4′-BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2007
Accepted
28 Jun 2007
First published
09 Jul 2007

Chem. Commun., 2007, 3765-3767

N-Methyl substituted 2′,4′-BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization

K. Miyashita, S. M. A. Rahman, S. Seki, S. Obika and T. Imanishi, Chem. Commun., 2007, 3765 DOI: 10.1039/B707352F

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