Issue 33, 2007
From the journal:

Dalton Transactions

η1-2-Pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): A delicate balance between stability and CO liberation

Ian J. S. Fairlamb,*a   Jason M. Lynam,*a   Benjamin E. Moulton,a   Ian E. Taylor,a   Anne K. Duhme-Klair,a   Philip Sawleb  and  Roberto Motterlini*b  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, UK
E-mail: ijsf1@york.ac.uk, jml12@york.ac.uk

b Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
E-mail: r.motterlini@imperial.ac.uk

Abstract

An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)3(η5-C5H5)(η1-{O}–C{[double bond, length as m-dash]O}–O–CMe[double bond, length as m-dash]CH-COMe[double bond, length as m-dash]CBr)]BF4 (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxity and vasodilatory properties of CORM-F10 have been determined.

Graphical abstract: η1-2-Pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): A delicate balance between stability and CO liberation

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Article information

DOI
https://doi.org/10.1039/B707377A
Article type
Communication
Submitted
16 May 2007
Accepted
01 Jun 2007
First published
29 Jun 2007

Dalton Trans., 2007, 3603-3605

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η1-2-Pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): A delicate balance between stability and CO liberation

I. J. S. Fairlamb, J. M. Lynam, B. E. Moulton, I. E. Taylor, A. K. Duhme-Klair, P. Sawle and R. Motterlini, Dalton Trans., 2007, 3603 DOI: 10.1039/B707377A

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