Issue 3, 2008

RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions

Abstract

Ras and its GTPase activating proteins (GAPs) are among the crucial regulators of extracelluar ligands. Information about these regulators has been elucidated during the course of studies in signal transduction over the last two decades. RasGAPs such as p120GAP and neurofibromin have been studied extensively for their roles as either “negative” regulators or effectors of Ras. Accumulating evidence suggests that these molecules are crucial regulators of extracellular stimuli that serve to maintain the homeostasis of cellular functions. This compendium highlights cellular functions of RasGAPs and their signaling characteristics from the viewpoint of homeostasis, including our recent finding of the phenotype of R-RasGAP mutant mice whose GAP activity is down-regulated.

Graphical abstract: RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions

Article information

Article type
Highlight
Submitted
23 Oct 2007
Accepted
22 Nov 2007
First published
08 Jan 2008

Mol. BioSyst., 2008,4, 213-222

RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions

S. Iwashita and S. Song, Mol. BioSyst., 2008, 4, 213 DOI: 10.1039/B716357F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements