Issue 15, 2008
From the journal:

Chemical Communications

Crystal structure and silica condensing activities of silicatein α–cathepsin L chimeras†‡

Michael Fairhead,§a   Kenneth A. Johnson,§b   Thomas Kowatz,§b   Stephen A. McMahon,b   Lester G. Carter,b   Muse Oke,b   Huanting Liu,b   James H. Naismith*b  and  Christopher F. van der Walle*a  

* Corresponding authors

a SIPBS, University of Strathclyde, 27 Taylor Street, Glasgow, Scotland, UK
E-mail: chris.walle@strath.ac.uk

b The Centre for Biomolecular Science and The Scottish Structural Proteomics Facility, University of St. Andrews, North Haugh, St. Andrews, Scotland, UK
E-mail: naismith@st-andrews.ac.uk

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 Å crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

Graphical abstract: Crystal structure and silica condensing activities of silicatein α–cathepsin L chimeras

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Article information

DOI
https://doi.org/10.1039/B718264C
Article type
Communication
Submitted
28 Nov 2007
Accepted
25 Jan 2008
First published
11 Feb 2008

Chem. Commun., 2008, 1765-1767

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Crystal structure and silica condensing activities of silicatein α–cathepsin L chimeras

M. Fairhead, K. A. Johnson, T. Kowatz, S. A. McMahon, L. G. Carter, M. Oke, H. Liu, J. H. Naismith and C. F. van der Walle, Chem. Commun., 2008, 1765 DOI: 10.1039/B718264C

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