One-pot three component synthesis of heteroarylated arylacetates viaVNSAr-SN reaction using N-methylpyrrolidone as general solvent

Song Cao; Jingjing Wu; Lina Li; Longjie Zhu; Jian Zhang; Jinlong Yu; Xuhong Qian

doi:10.1039/B719185E

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One-pot three component synthesis of heteroarylated arylacetates viaVNS_Ar-S_N reaction using N-methylpyrrolidone as general solvent†

Song Cao,*^a Jingjing Wu,^a Lina Li,^a Longjie Zhu,^a Jian Zhang,^a Jinlong Yu^a and Xuhong Qian^a

Author affiliations

* Corresponding authors

^a Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, Shanghai, China
E-mail: scao@ecust.edu.cn
Fax: +86 21-6425-2603

Abstract

An efficient three component one-pot method was developed to assemble 2-heteroaryl-2-aryl acetates viaVNS_Ar-S_NAr and VNS_Ar-S_N reaction by using N-methylpyrrolidone (NMP) as general solvent.

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Supplementary files

NMR and mass spectra of products PDF (10545K)

Article information

DOI: https://doi.org/10.1039/B719185E
Article type: Paper
Submitted: 12 Dec 2007
Accepted: 13 Feb 2008
First published: 27 Feb 2008

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Org. Biomol. Chem., 2008,6, 1293-1297

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One-pot three component synthesis of heteroarylated arylacetates viaVNS_Ar-S_N reaction using N-methylpyrrolidone as general solvent

S. Cao, J. Wu, L. Li, L. Zhu, J. Zhang, J. Yu and X. Qian, Org. Biomol. Chem., 2008, 6, 1293 DOI: 10.1039/B719185E

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Organic & Biomolecular Chemistry