Issue 7, 2008
From the journal:

Organic & Biomolecular Chemistry

Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1

Matthew O'Brien,*a   Alejandro Diéguez-Vázquez,a   Day-Shin Hsu,a   Helmut Kraus,a   Yukihito Suminoa  and  Steven V. Leya  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: mo263@cam.ac.uk
Fax: +44 (0) 1223 336442
Tel: +44 (0) 1223 336398

Abstract

Azeotropic reflux chromatography (in which the eluent is continuously recycled by means of refluxing) was used to separate a mixture of spiroketal intermediates in the scale-up synthesis of spongistatin 1, leading to an improved separation and an approximately 35-fold reduction in the amount of solvent used.

Graphical abstract: Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1

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Article information

DOI
https://doi.org/10.1039/B719569A
Article type
Communication
Submitted
19 Dec 2007
Accepted
25 Jan 2008
First published
19 Feb 2008

Org. Biomol. Chem., 2008,6, 1159-1164

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Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1

M. O'Brien, A. Diéguez-Vázquez, D. Hsu, H. Kraus, Y. Sumino and S. V. Ley, Org. Biomol. Chem., 2008, 6, 1159 DOI: 10.1039/B719569A

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