Issue 6, 2008
From the journal:

Green Chemistry

Fast, quantitative nucleoside protection under solvent-free conditions

Nicola Giri,a   Caroline Bowen,a   Joseph S. Vyle*a  and  Stuart L. James*a  

* Corresponding authors

a Innovative Molecular Materials (IMM) Group and Centre for the Theory and Application of Catalysis (CentTACat), School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, Northern Ireland, UK
E-mail: j.vyle@qub.ac.uk, s.james@qub.ac.uk
Fax: +44 (0)28 90972117
Tel: +44 (0)28 90975419

Abstract

Persilylation of nucleoside hydroxyls was effected in quantitative yields under solvent-free conditions using a ball mill. In addition, one-pot persilylation and acylation of cytidine was performed as an exemplar reaction demonstrating the utility of solvent-free approaches to nucleoside chemistry.

Graphical abstract: Fast, quantitative nucleoside protection under solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/B801455H
Article type
Communication
Submitted
25 Jan 2008
Accepted
16 Apr 2008
First published
30 Apr 2008

Green Chem., 2008,10, 627-628

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Fast, quantitative nucleoside protection under solvent-free conditions

N. Giri, C. Bowen, J. S. Vyle and S. L. James, Green Chem., 2008, 10, 627 DOI: 10.1039/B801455H

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