Issue 7, 2008
From the journal:

Organic & Biomolecular Chemistry

Electronic and steric effects on the rate of the traceless Staudinger ligation†

Annie Tam,a   Matthew B. Soellner‡a  and  Ronald T. Raines*ab  

* Corresponding authors

a Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA

b Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA
E-mail: rtraines@wisc.edu

Abstract

Interplay between electronic effects imparted by phosphinothiol substituents and steric effects imposed by amino-acid reactants affects the rate of the traceless Staudinger ligation of peptides in a predictable manner.

Graphical abstract: Electronic and steric effects on the rate of the traceless Staudinger ligation

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Article information

DOI
https://doi.org/10.1039/B802336K
Article type
Communication
Submitted
11 Feb 2008
Accepted
20 Feb 2008
First published
03 Mar 2008

Org. Biomol. Chem., 2008,6, 1173-1175

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Electronic and steric effects on the rate of the traceless Staudinger ligation

A. Tam, M. B. Soellner and R. T. Raines, Org. Biomol. Chem., 2008, 6, 1173 DOI: 10.1039/B802336K

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