Issue 22, 2008
From the journal:

Chemical Communications

Oxidative radical cyclisations for the synthesis of γ-lactones†

Luke H. Powell,ab   Paul H. Docherty,ab   David G. Hulcoop,a   Paul D. Kemmittc  and  Jonathan W. Burton*ab  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

b Chemistry Research Laboratory, Mansfield Road, Oxford, UK
E-mail: jonathan.burton@chem.ox.ac.uk
Fax: +44 1865 285002
Tel: +44 1865 285119

c AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

Abstract

The use of manganese(III) acetate in combination with copper(II) triflate allows the synthesis of [3.3.0]-bicyclic γ-lactones from 4-pentenylmalonates in excellent yields.

Graphical abstract: Oxidative radical cyclisations for the synthesis of γ-lactones

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Article information

DOI
https://doi.org/10.1039/B802473A
Article type
Communication
Submitted
13 Feb 2008
Accepted
31 Mar 2008
First published
21 Apr 2008

Chem. Commun., 2008, 2559-2561

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Oxidative radical cyclisations for the synthesis of γ-lactones

L. H. Powell, P. H. Docherty, D. G. Hulcoop, P. D. Kemmitt and J. W. Burton, Chem. Commun., 2008, 2559 DOI: 10.1039/B802473A

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