Issue 30, 2008
From the journal:

Chemical Communications

Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade†

Akinori Okano,a   Tsuyoshi Mizutani,b   Shinya Oishi,a   Tetsuaki Tanaka,b   Hiroaki Ohno*a  and  Nobutaka Fujii*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Japan
E-mail: hohno@pharm.kyoto-u.ac.jp, nfujii@pharm.kyoto-u.ac.jp

b Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Japan

Abstract

Treatment of allenic bromoalkenes bearing a nucleophilic moiety with a catalytic amount of palladium(0) in the presence of TBAF or Cs2CO3 in MeCNaffords bicyclic heterocycles in good to high yields, through zipper-mode cascade cyclisation.

Graphical abstract: Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade

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Article information

DOI
https://doi.org/10.1039/B805845H
Article type
Communication
Submitted
07 Apr 2008
Accepted
05 May 2008
First published
20 Jun 2008

Chem. Commun., 2008, 3534-3536

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Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade

A. Okano, T. Mizutani, S. Oishi, T. Tanaka, H. Ohno and N. Fujii, Chem. Commun., 2008, 3534 DOI: 10.1039/B805845H

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