Controlling the formation of 1 out of 64 stereoisomers using organocatalysis

Abstract

The formation of 1 out of 64 stereoisomers, i.e. controlling the creation of 6 stereocenters, of important optically active bicyclo[3.3.1]non-2-ene compounds, has been achieved using organocatalysis; the reaction proceeds with excellent stereocontrol and can be carried out with the generation of enantiopure products using chromatography-free procedures.