Issue 43, 2008

Chemoenzymatic synthesis of chiral 4,4′-bipyridyls and their metal–organic frameworks

Abstract

The first enantiopure 4,4′-bipyridyls, 6, 8, and 9 have been prepared in four or five steps via bacterial dioxygenase-catalysed cis-dihydroxylation of 4-chloroquinoline1 and C–C coupling; ligands 6 and 9 are found to be effective building blocks for the preparation of chiral metal–organic frameworks as demonstrated with the rational synthesis of two pillared-grid structures [Zn2(fumarate)2(L)], which exhibit interesting structural and dynamic aspects.

Graphical abstract: Chemoenzymatic synthesis of chiral 4,4′-bipyridyls and their metal–organic frameworks

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2008
Accepted
11 Sep 2008
First published
09 Oct 2008

Chem. Commun., 2008, 5538-5540

Chemoenzymatic synthesis of chiral 4,4′-bipyridyls and their metal–organic frameworks

L. Sbircea, N. D. Sharma, W. Clegg, R. W. Harrington, P. N. Horton, M. B. Hursthouse, D. C. Apperley, D. R. Boyd and S. L. James, Chem. Commun., 2008, 5538 DOI: 10.1039/B812366G

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