Issue 43, 2008

Cymantreneconjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide

Abstract

The conjugation of cymantreneCpMn(CO)3 to cell-penetrating peptide hCT(18-32)-k7 alters the intracellular distribution in MCF-7 cells compared to the unmodified peptide, as visualized by fluorescence microscopy, and leads to an increased nuclear accumulation; the peptide and cymantrene compound themselves are not toxic, but the bioconjugate shows a significant cytotoxicity with an IC50 value of 36 μmol l−1.

Graphical abstract: Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide

Supplementary files

Article information

Article type
Communication
Submitted
25 Jul 2008
Accepted
12 Sep 2008
First published
26 Sep 2008

Chem. Commun., 2008, 5604-5606

Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide

I. Neundorf, J. Hoyer, K. Splith, R. Rennert, H. W. Peindy N’Dongo and U. Schatzschneider, Chem. Commun., 2008, 5604 DOI: 10.1039/B812799A

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