Issue 10, 2009
From the journal:

Chemical Communications

Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein†

Takumi Ishizuka,a   Kosuke Otani,a   Jun Sumaoka*a  and  Makoto Komiyama*a  

* Corresponding authors

a Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan
E-mail: sumaoka@mkomi.rcast.u-tokyo.ac.jp, komiyama@mkomi.rcast.u-tokyo.ac.jp
Fax: +81-3-5452-5209
Tel: +81-3-5452-5200

Abstract

In the presence of single-stranded DNA binding protein(SSB), conventional peptide nucleic acid (PNA) without chemical modifications efficiently invades into arbitrary sequences in DNA.

Graphical abstract: Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein

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Article information

DOI
https://doi.org/10.1039/B813975J
Article type
Communication
Submitted
12 Aug 2008
Accepted
02 Dec 2008
First published
14 Jan 2009

Chem. Commun., 2009, 1225-1227

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Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein

T. Ishizuka, K. Otani, J. Sumaoka and M. Komiyama, Chem. Commun., 2009, 1225 DOI: 10.1039/B813975J

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