Issue 48, 2008
From the journal:

Chemical Communications

Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation†

Mazen Sleiman,‡b   Annabelle Varrot,*c   Jean-Manuel Raimundo,‡a   Marc Gingras‡*a  and  Peter G. Goekjian*b  

* Corresponding authors

a Interdisciplinary Center on Nanoscience of Marseille (CINaM), UPR CNRS 3118, (affiliated with Université de la Méditerranée), Campus de Luminy, Case 913, Marseille, Cedex 9, France
E-mail: marc.gingras@univmed.fr
Fax: (+33)491829155
Tel: (+33)491829155

b Laboratoire de Chimie Organique II-Glycochimie, UMR CNRS 5246, Université Claude Bernard – Lyon 1, C.P.E. Lyon, Bâtiment 308D, 43 Boulevard du 11 Novembre 1918, Villeurbanne Cedex, France
E-mail: goekjian@univ-lyon1.fr
Fax: (+33) 478898914
Tel: (+33) 472448183

c Centre de Recherches sur les Macromolécules Végétales (CERMAV), UPR CNRS 5301 (affiliated with Université Joseph Fourier), 601 rue de la Chimie, BP 53, Grenoble Cedex 9, France
E-mail: annabelle.varrot@cermav.cnrs.fr

Abstract

A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the α-D-mannose asterisk.

Graphical abstract: Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

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Article information

DOI
https://doi.org/10.1039/B814816C
Article type
Communication
Submitted
26 Aug 2008
Accepted
30 Sep 2008
First published
07 Nov 2008

Chem. Commun., 2008, 6507-6509

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Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

M. Sleiman, A. Varrot, J. Raimundo, M. Gingras and P. G. Goekjian, Chem. Commun., 2008, 6507 DOI: 10.1039/B814816C

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